I think you should also be asking whether it is 32 or 64 bit. It would appear it makes a vast difference.
I have 64 bit vista ultimate oem version and consequently I am experiencing quite a few problems.
Zone Alarm, Line One Care, Roxio 7, Big Fish Games, Norton Ghost 9, TV Tuner Card to name but a few. Some of the applications specifically state that they are not compatible with 64 bit edition.
Real Arcade will run MOST games PROVIDED you run the program as an administrator. Also my Tevion DVB-T